Abstract
PART IIn chapter 2, the relationship between perfusion and hypoxia has been investigated with15O-H2O en 18F-FAZA, respectively. In chapter 3 the relationship between perfusion and proliferation with 15O-H2O and18F-FLT was investigated. PART IIIn chapter 4A and 4B, the biodistribution of 18F-FES has been described and it has beeninvestigated how this is affected by rintodestrant, a novel SERD. In chapter 5 the pharmacokinetic profile of the 18F-FES radiotracer was investigated inpatients with metastatic ER+ breast cancer.In chapter 6 it was investigated how the diagnostic accuracy is of 18F-FDG, the radiotracerthat is currently used for staging of ER+ disease. In chapter 7, it was investigated how 18F-FDG versus 18F-FES heterogeneity predicts response to therapy and/or allows to monitor treatment effect.
| Original language | English |
|---|---|
| Qualification | PhD |
| Awarding Institution |
|
| Supervisors/Advisors |
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| Award date | 12 Oct 2023 |
| Print ISBNs | 9789464731743 |
| DOIs | |
| Publication status | Published - 12 Oct 2023 |
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10.5463/thesis.292Licence: CC BY-ND
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Bridging the gap
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Iqbal, R. (2023). Bridging the gap: from methodological developments towards clinical implementation of imaging biomarkers in lung and breast cancer. [PhD-Thesis - Research and graduation internal, Vrije Universiteit Amsterdam]. https://doi.org/10.5463/thesis.292
Iqbal, Ramsha. / Bridging the gap : from methodological developments towards clinical implementation of imaging biomarkers in lung and breast cancer. 2023. 230 p.
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title = "Bridging the gap: from methodological developments towards clinical implementation of imaging biomarkers in lung and breast cancer",
abstract = "PART I In chapter 2, the relationship between perfusion and hypoxia has been investigated with 15O-H2O en 18F-FAZA, respectively. In chapter 3 the relationship between perfusion and proliferation with 15O-H2O and 18F-FLT was investigated. PART II In chapter 4A and 4B, the biodistribution of 18F-FES has been described and it has been investigated how this is affected by rintodestrant, a novel SERD. In chapter 5 the pharmacokinetic profile of the 18F-FES radiotracer was investigated in patients with metastatic ER+ breast cancer. In chapter 6 it was investigated how the diagnostic accuracy is of 18F-FDG, the radiotracer that is currently used for staging of ER+ disease. In chapter 7, it was investigated how 18F-FDG versus 18F-FES heterogeneity predicts response to therapy and/or allows to monitor treatment effect.",
author = "Ramsha Iqbal",
year = "2023",
month = oct,
day = "12",
doi = "10.5463/thesis.292",
language = "English",
isbn = "9789464731743",
type = "PhD-Thesis - Research and graduation internal",
school = "Vrije Universiteit Amsterdam",
}
Iqbal, R 2023, 'Bridging the gap: from methodological developments towards clinical implementation of imaging biomarkers in lung and breast cancer', PhD, Vrije Universiteit Amsterdam. https://doi.org/10.5463/thesis.292
Bridging the gap: from methodological developments towards clinical implementation of imaging biomarkers in lung and breast cancer. / Iqbal, Ramsha.
2023. 230 p.
Research output: PhD Thesis › PhD-Thesis - Research and graduation internal
TY - THES
T1 - Bridging the gap
T2 - from methodological developments towards clinical implementation of imaging biomarkers in lung and breast cancer
AU - Iqbal, Ramsha
PY - 2023/10/12
Y1 - 2023/10/12
N2 - PART IIn chapter 2, the relationship between perfusion and hypoxia has been investigated with15O-H2O en 18F-FAZA, respectively. In chapter 3 the relationship between perfusion and proliferation with 15O-H2O and18F-FLT was investigated. PART IIIn chapter 4A and 4B, the biodistribution of 18F-FES has been described and it has beeninvestigated how this is affected by rintodestrant, a novel SERD. In chapter 5 the pharmacokinetic profile of the 18F-FES radiotracer was investigated inpatients with metastatic ER+ breast cancer.In chapter 6 it was investigated how the diagnostic accuracy is of 18F-FDG, the radiotracerthat is currently used for staging of ER+ disease. In chapter 7, it was investigated how 18F-FDG versus 18F-FES heterogeneity predicts response to therapy and/or allows to monitor treatment effect.
AB - PART IIn chapter 2, the relationship between perfusion and hypoxia has been investigated with15O-H2O en 18F-FAZA, respectively. In chapter 3 the relationship between perfusion and proliferation with 15O-H2O and18F-FLT was investigated. PART IIIn chapter 4A and 4B, the biodistribution of 18F-FES has been described and it has beeninvestigated how this is affected by rintodestrant, a novel SERD. In chapter 5 the pharmacokinetic profile of the 18F-FES radiotracer was investigated inpatients with metastatic ER+ breast cancer.In chapter 6 it was investigated how the diagnostic accuracy is of 18F-FDG, the radiotracerthat is currently used for staging of ER+ disease. In chapter 7, it was investigated how 18F-FDG versus 18F-FES heterogeneity predicts response to therapy and/or allows to monitor treatment effect.
U2 - 10.5463/thesis.292
DO - 10.5463/thesis.292
M3 - PhD-Thesis - Research and graduation internal
SN - 9789464731743
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Iqbal R. Bridging the gap: from methodological developments towards clinical implementation of imaging biomarkers in lung and breast cancer. 2023. 230 p. doi: 10.5463/thesis.292
